5-(4,4,5,5-Teteramethyl-[1,3,2]dioxaboroane-2-yl)-nicotinic acid ethyl ester
ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
CAS: 916326-10-8
Molecular Formula: C14H20BNO4
5-(4,4,5,5-Teteramethyl-[1,3,2]dioxaboroane-2-yl)-nicotinic acid ethyl ester - Names and Identifiers
5-(4,4,5,5-Teteramethyl-[1,3,2]dioxaboroane-2-yl)-nicotinic acid ethyl ester - Physico-chemical Properties
| Molecular Formula | C14H20BNO4 |
| Molar Mass | 277.12 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
5-(4,4,5,5-Teteramethyl-[1,3,2]dioxaboroane-2-yl)-nicotinic acid ethyl ester - Introduction
Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is an organic compound with the formula C15H21BNO5.
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: about 70-72 ℃
-Solubility: Soluble in most organic solvents such as ether, dichloromethane and methanol
Use:
-as an important reagent and intermediate in organic synthesis
-can be used to synthesize compounds containing pyridine skeleton
-In the field of drug synthesis and pesticide synthesis and other applications
Method:
the preparation of ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate can be completed by ester exchange reaction, the specific steps are as follows:
1.5-Chloro -2,3-dimethylpyridine reacts with ethyl acetate under alkaline conditions to generate ethyl N-(5-chloro-2, 3-dimethylpyridin-2-yl) acetate.
2. the product obtained in the previous step is subjected to palladium-catalyzed transesterification reaction with 4,4,5,5-tetramethyl-1,3, 2-dioxole-2-ene-2-boronic acid to produce the final product ethyl 5-(4,4, 5,5-tetramethyyl-1, 3,2-dioxaborolan-2-yl)nicotinate.
Safety Information:
ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate has limited safety information, so general chemical laboratory safety procedures should be followed during operation or use. This includes wearing appropriate personal protective equipment (e. g., lab gloves, goggles, lab coats, etc.) and avoiding inhalation, ingestion, or contact with the compound. When using this compound, ensure that the operating environment is well ventilated and that waste is properly disposed. In case of inhalation, ingestion or skin contact, seek medical attention immediately.
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: about 70-72 ℃
-Solubility: Soluble in most organic solvents such as ether, dichloromethane and methanol
Use:
-as an important reagent and intermediate in organic synthesis
-can be used to synthesize compounds containing pyridine skeleton
-In the field of drug synthesis and pesticide synthesis and other applications
Method:
the preparation of ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate can be completed by ester exchange reaction, the specific steps are as follows:
1.5-Chloro -2,3-dimethylpyridine reacts with ethyl acetate under alkaline conditions to generate ethyl N-(5-chloro-2, 3-dimethylpyridin-2-yl) acetate.
2. the product obtained in the previous step is subjected to palladium-catalyzed transesterification reaction with 4,4,5,5-tetramethyl-1,3, 2-dioxole-2-ene-2-boronic acid to produce the final product ethyl 5-(4,4, 5,5-tetramethyyl-1, 3,2-dioxaborolan-2-yl)nicotinate.
Safety Information:
ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate has limited safety information, so general chemical laboratory safety procedures should be followed during operation or use. This includes wearing appropriate personal protective equipment (e. g., lab gloves, goggles, lab coats, etc.) and avoiding inhalation, ingestion, or contact with the compound. When using this compound, ensure that the operating environment is well ventilated and that waste is properly disposed. In case of inhalation, ingestion or skin contact, seek medical attention immediately.
Last Update：2024-04-09 20:49:11
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Product Name: 3-(ETHOXYCARBONYL)PYRIDINE-5-BORONIC ACID PINACOL ESTER Visit Supplier Webpage Request for quotation
CAS: 916326-10-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 916326-10-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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